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Eplerenone moderate olanzapine may induce orthostatic hypotension and thus enhance the effects of antihypertensive agents.

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olanzapine is a cyp2d6 substrate and quinine is a cyp2d6 inhibitor.

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because olanzapine is known to cross the placenta in animals, the drug is recommended for use during pregnancy only when the benefits outweigh the risks.

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primidone moderate olanzapine is metabolized by the cyp1a2 hepatic microsomal isoenzyme, and inducers of this enzyme such as barbiturates, may increase olanzapine clearance.

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alcohol ethanol 45 mg 70 kg single dose did not have an effect on olanzapine pharmacokinetics.

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a 2 4 week injection within the therapeutic dose range provides similar plasma concentrations to those achieved by therapeutic daily doses of oral olanzapine.

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