In pooled, controlled clinical trials in pediatric patients 2 to 15 years of age with partial onset seizures, primary generalized tonic-clonic seizures, or lennox-gastaut syndrome, 98 patients received adjunctive therapy with topamax at dosages of 5 to 9 mg kg day recommended dose range and 101 patients received placebo.
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the effect of topamax on growth and bone-related sequelae has not been systematically investigated in long-term, placebo-controlled trials.
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